作者采用双盲、安慰对比交叉试验的方法,在12例痉挛状态和8例肌强直患者中研究观察了肉毒素A的治疗效果。 痉挛状态组的12例中,男3例,女9例。年龄12～81岁,平均50.2岁。强直组的8例中,男5例,女3例。年龄57～83岁,平均66.3岁。治疗前和治疗后两周分别对肌张力进行分级评估。 方法:用0.9％氯化钠稀释冻干毒素制剂后,根据肌组织大小从小剂量开始局部注射,并用等量盐水安慰对比注射。大块肌组织注射20～120单位,小 The authors used a double-blind, comfort-matched crossover study to examine the efficacy of botulinum toxin A in 12 patients with spasticity and 8 patients with myotonia. Spasm group of 12 cases, 3 males and 9 females. Aged 12 to 81 years old, with an average of 50.2 years old. 8 cases of tonic group, 5 males and 3 females. Aged 57 to 83 years old, with an average of 66.3 years old. Muscle tension was assessed before treatment and two weeks after treatment, respectively. Methods: Dilute the lyophilized toxin preparation with 0.9% sodium chloride, then start local injection according to the size of the muscle from a small dose, and administer an equivalent injection with an equal amount of saline. Large muscle tissue injection 20 ~ 120 units, small