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目的:探讨免疫球蛋白联合激素治疗小儿格林-巴利综合征的疗效。方法:格林-巴利综合征患儿55例按照治疗方法不同分为联合治疗组32例(观察组)和单独治疗组23例(对照组)。对照组给予免疫球蛋白400mg/(kg.d),静脉注射,疗程5d;观察组在对照组治疗基础上给予甲基强的松龙。结果:观察组显效率、24h总有效率均优于对照组(P<0.05);观察组呼吸肌麻痹、四肢肌力、肌张力、腱反射、感觉障碍恢复时间较对照组短(P<0.05)。结论:在控制好激素不良反应前提下,免疫球蛋白联合激素治疗小儿格林-巴利综合征疗效优于单用免疫球蛋白治疗。
Objective: To investigate the effect of immunoglobulin combined with hormonal treatment of children with Guillain-Barre syndrome. Methods: Fifty-five children with Guillain-Barre syndrome were divided into treatment group (32 cases) and control group (23 cases). The control group was given immunoglobulin 400mg / (kg.d), intravenous injection, the course of treatment 5d; the observation group was given methylprednisolone on the basis of the control group. Results: The effective rate of observation group and total effective rate of 24h were better than that of control group (P <0.05). Respiratory muscle paralysis, limb muscle strength, muscle tone, tendon reflex and sensory recovery time in observation group were shorter than those in control group ). Conclusion: Under the precondition of controlling the hormone adverse reaction, immunoglobulin combined with hormone treatment of children with Guillain-Barre syndrome is superior to single immunoglobulin therapy.