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目的探讨细胞膜及细胞核内表皮生长因子受体(EGFR)水平与非小细胞肺癌(NSCLC)预后之间的关系。方法选取2010年4月至2013年4月间南京市溧水区人民医院保存的60例非小细胞肺癌患者的病理档案,采用免疫组化的方法分析其病理组织切片中细胞膜及细胞核内EGFR及细胞周期蛋白D1(Cyclin D1)的表达。结果 39例(65.0%)样本细胞膜EGFR呈阳性,7例(11.7%)样本细胞膜EGFR呈强阳性;18例(30.0%)样本细胞核EGFR呈阳性和5例(8.3%)样本细胞核EGFR呈强阳性。Kaplan-Meier生存分析和Log-rank检验发现非小细胞肺癌患者细胞膜EGFR强阳性与总体生存率(OS)无明显相关,差异无统计学意义(P>0.05),细胞核EGFR强阳性组与总体生存率(OS)呈负相关,差异有统计学意义(P<0.01)。细胞核EGFR表达水平与Cyclin D1之间正相关,差异有统计学意义(P<0.05),细胞膜EGFR表达水平与Cyclin D1之间无明显相关,差异无统计学意义(P>0.05)。结论细胞核内EGFR水平与非小细胞肺癌患者的预后相关,核内EGFR强阳性者预后差。
Objective To investigate the relationship between the level of epidermal growth factor receptor (EGFR) in the cell membrane and the nucleus and the prognosis of non-small cell lung cancer (NSCLC). Methods From April 2010 to April 2013, 60 cases of non-small cell lung cancer (NSCLC) preserved in Lishui District People’s Hospital of Nanjing were enrolled in this study. Immunohistochemistry was used to analyze the expression of EGFR and cell in the cell membrane and nucleus Cyclin D1 expression. Results EGFR was positive in 39 samples (65.0%) and EGFR in 7 samples (11.7%). EGFR was positive in 18 samples (30.0%) and strong positive in 5 samples (8.3%) . Kaplan-Meier survival analysis and Log-rank test showed that there was no significant correlation between strong positive EGFR and overall survival (OS) in non-small cell lung cancer patients (P> 0.05) Rate (OS) was negatively correlated, the difference was statistically significant (P <0.01). There was a positive correlation between the expression of EGFR and Cyclin D1 (P <0.05). There was no significant difference between the expression of EGFR and Cyclin D1 (P> 0.05). Conclusion The level of EGFR in the nucleus is related to the prognosis of patients with non-small cell lung cancer. The prognosis of patients with strong EGFR in the nucleus is poor.