Silica-supported CuCo catalysts were prepared by impregnation method with different impregnation sequence for higher alcohols synthesis.These catalysts were characterized by H_2-TPR,XRD,N_2 adsorption,XPS techniques and CO selective hydrogenation reaction measurement.The effects of impregnation sequence on the structure and performance of cata- lysts were investigated,and there were important influences on the selectivity to higher alcohols.There was a strong synergistic effect between copper and cobalt for the co-impregnated sample.The CuCo/SiO_2 catalyst prepared by co-impregnation showed a better yield of total alcohols,and a higher selectivity to total alcohols which reached 51.5%. Silica-supported CuCo catalysts were prepared by impregnation method with different impregnation sequence for higher alcohol synthesis.These catalysts were characterized by H_2-TPR, XRD, N_2 adsorption, XPS techniques and CO selective hydrogenation reaction measurement.The effects of impregnation sequence on the structure and performance of cata- lysts were investigated, and there were important influences on the selectivity to higher alcohols. There was a strong synergistic effect between copper and cobalt for the co-impregnated sample. The CuCo / SiO 2 catalyst prepared by co-impregnation showed a better yield of total alcohols, and a higher selectivity to total alcohols which reached 51.5%.