长期以来,解热镇痛药被认为是非常安全的;其毒性一直未受到注意。再者解热镇痛药往往与其他药物联合应用,随意购服,因此要正确识别药物的严重不良反应几乎不太可能。 1953年瑞士的Spuhler和Zollinger首先报道了44例原因不明的晚期肾病患者,其中多数人曾服用大量复方镇痛药物。此后澳大利亚、瑞士、斯堪的纳维亚及苏格兰亦见类似报告。患者的共同特点似乎都有非那西汀的服用史,故曾称之为“非那西汀肾炎”。50～60年代在文 Antipyretics and analgesics have long been considered to be very safe; their toxicity has not been noticed. Furthermore, antipyretic analgesics often combined with other drugs, free to buy clothes, so to correctly identify the serious side effects of drugs is almost impossible. In 1953 Switzerland’s Spuhler and Zollinger first reported 44 patients with unexplained advanced renal disease, most of whom had taken a large number of compound analgesics. Similar reports have been made since then in Australia, Switzerland, Scandinavia and Scotland. The common features of patients seem to have been taking phenacetin, it was called “phenacetin nephritis.” 50 ~ 60 years in the text