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五十年代中期孕激素和雌激素的联合应用使抗生育药物的研究获得成功,在其后的二十多年中甾体避孕药的研究进展很快,但该类药物在临床上使用还存在一些问题,如内分泌失调等。为了寻找更理想的避孕药,非甾体抗生育药物的研究也逐渐受到重视,W.Yuduin 在1955年首先报道了右旋地衣酸具有抗着床作用,随后相继发现一些生物烷化剂、抗有丝分裂药物、抗组胺药物、单胺氧化酶抑制剂、麦角生物碱、安定药物等都具有不同程度的抗生育作用,鉴于抗生育药物系供健康人长期使用,这就要求药物的作用可逆、无致畸、致癌,致诱变等毒副作用,因此限制了上述药物的进一步研究.
The combined use of progesterone and estrogen in the mid-1950s led to the success of anti-fertility drug research and the rapid development of steroid contraceptives in the subsequent two decades, but the clinical use of these drugs still exists Some problems, such as endocrine disorders. In order to find a more ideal contraceptive, non-steroidal anti-fertility drug research has gradually been taken seriously, W. Yuduin first reported in 1955, D-lichenamic acid has anti-implantation effect, followed by the discovery of some biological alkylating agents, anti- Mitotic drugs, antihistamines, monoamine oxidase inhibitors, ergot alkaloids, diazepam drugs have varying degrees of anti-fertility effects, given the anti-fertility drugs for the long-term use of healthy people, which requires the role of drug reversible, non-teratogenic , Carcinogenic, mutagenic and other toxic side effects, thus limiting the further study of the above drugs.