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决定气雾剂沉积在肺内部位的因素包括各种与粒子有关的因素和与气道有关的因素,诸如气流速度,潮气量,呼吸速度和气道管径.自然发生的气雾剂的大小、形状和密度变化很大,大多数治疗用的气雾剂弥散的程度是不均匀的.应该强调,吸入气流的速度由于冲击的作用而决定沉积的多少,这点是很重要的.大多数气雾剂药物主要由重力的作用而沉积,肺容量和呼吸速度对决定沉积效率和粒子弥散是很重要的.
Factors that determine aerosol deposition within the lung include various particle-related factors and airway-related factors such as airflow velocity, tidal volume, respiratory rate, and airway diameter, the size of the aerosol that naturally occurs, The shape and density vary widely, and most therapeutic aerosols disperse unevenly.It should be emphasized that it is important that the speed of the inhaled air flow be determined by how much impact is deposited, and most of the gas Aerosol drugs are mainly deposited by the action of gravity, and lung volume and respiration rate are important in determining deposition efficiency and particle dispersion.