观察５２例纤维胃镜咬取的十二指肠粘膜标本，组织学显示９８％有慢性炎，８０％为萎缩性炎。按粘膜绒毛高度和萎缩程度分轻、中、重３级。结合临床，中、重度萎缩性十二指肠炎，可作为小肠吸收不良的诊断依据。５２例中，有ＭＧＥ、Ｂｒｕｎｎｅｒ’ｓ腺增生分别为２１％和５０％。组织化学染色证实十二指肠杯状细胞含混合性粘液。 52 cases of endoscopic mucosal biopsies were observed by gastroscopy. Histology showed that 98% had chronic inflammation and 80% had atrophic inflammation. According to mucosal villus height and atrophy degree of light, medium and heavy 3. Combined with clinical, moderate and severe atrophic duodenitis, can be used as a diagnosis of poor intestinal absorption. In 52 cases, MGE and Brunner’s gland hyperplasia were 21% and 50%, respectively. Histochemical staining confirmed that duodenal goblet cells contained mixed mucus.