文献报道的动力学参数多数取平均值,但个体之间,如:急性心衰、肾衰、肝损害和烧伤等病人,存有差异性。因而,文献数据仅供参考用。有人提出个体病人的动力学参数的简便测定法,然后制订给药方案,其中Ritschel等人提出的重复一点法(ROPM)较实用。本文着重介绍重复一点法,求得参数后,制订非等间隔给药的剂量方案; Most of the kinetic parameters reported in the literature are averaged, but there are differences between individuals such as acute heart failure, renal failure, liver damage and burns. Therefore, the literature data is for reference only. Someone proposed a simple method for the determination of kinetic parameters of individual patients, and then formulated the dosing regimen, in which Ritschel et al. Proposed the ROPM method to be more practical. This article focuses on the repeated point method, to obtain the parameters, formulate a non-interval dose dosing program;