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近来,在重症肌无力病肌的运动终板处查到了免疫复合物;但是,在实验性自体免疫性重症肌无力(EAMG)中,该复合物的所在部位至今才得证实。作者等用提纯了的电鋪(Tovpido)乙酰胆硷受体加上佐剂与百日咳疫苗免疫大鼠(6只),造成EAMG;另对3只大鼠,只给佐剂与百日咳疫苗,作为对照。在一定时期后,从所有大鼠的前肢取材,作IgG、C_3的超显微结构定位,并进行有关体外微终板电位(Mepp)的观察。结果在对照动物的终板处不见IgG与C_3。而在EAMG中,其终板突触后膜的皱褶膨大部分有IgG与C_3结合,该处正是乙酰胆硷受体(AchR)的所在地;在终板间隙散布着小球状退变物质,亦结合有
Recently, immune complexes have been found at the motor end plates of myasthenia gravis muscles; however, the site of the complex has so far been confirmed in experimental autoimmune myasthenia gravis (EAMG). The authors used a purified Tovpido acetylcholine receptor plus adjuvant and pertussis vaccine in rats (6), resulting in EAMG; the other 3 rats, only adjuvants and pertussis vaccine, as Control. After a certain period of time, the forelimbs of all rats were taken for the localization of IgG and C_3 ultrastructures, and the observation of the in vitro microcalcifications (Mepp) was performed. As a result, IgG and C_3 were not seen at the end plate of control animals. In EAMG, the end-plate postsynaptic membrane folds have some IgG and C_3 binding, which is where the acetylcholine receptor (AchR) is located; in the end plate interspersed with small globules of degenerative material, Also combined with