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目的探讨非小细胞肺癌组织中趋化因子受体7(CCR7)的表达及其临床意义。方法采用免疫组织化学法检测经外科手术切除的60例非小细胞肺癌组织及15例癌旁组织标本中CCR7的表达情况。结果肺癌组织中CCR7阳性细胞表达率较癌旁组织明显增加;有淋巴结转移组的CCR7阳性细胞浸润程度明显高于无淋巴结转移组的;Ⅲ～Ⅳ期肺癌CCR7阳性表达率明显高于Ⅰ～Ⅱ期。上述差异均有统计学意义(均P<0.05)。结论非小细胞肺癌组织中CCR7表达与肺癌临床分期及淋巴结转移有关,可能参与肺癌的免疫逃逸和疾病进展。
Objective To investigate the expression of chemokine receptor 7 (CCR7) in non-small cell lung cancer and its clinical significance. Methods Immunohistochemical method was used to detect the expression of CCR7 in 60 cases of non-small cell lung cancer and 15 cases of adjacent tissues. Results The positive rate of CCR7 positive cells in lung cancer tissues was significantly higher than that in adjacent non-cancerous tissues. The positive rate of CCR7 positive cells in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group. The positive rate of CCR7 in stage Ⅲ ~ Ⅳ lung cancer was significantly higher than that in Ⅰ ~ Ⅱ period. The above differences were statistically significant (all P <0.05). Conclusion The expression of CCR7 in non-small cell lung cancer is related to the clinical stage and lymph node metastasis of lung cancer, which may be involved in the immune escape and disease progression of lung cancer.