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青霉素类药物属β-内酰胺类抗生素,其水溶液不稳定,在常温(25℃)下,24h内约一半以上的药物裂解。随之不仅抗菌作用明显降低,而且降解产物进入人体后可与自蛋白结合,引起一系列免疫反应,使过敏反应的发生率显著增高。因此,一日剂量加入葡萄糖等溶液内缓慢静滴,显然不恰当。如将一日剂量1次肌注,或在短时间内静滴,虽可避免以上缺陷,但极大多数青霉素类品种的半衰期很短,约1h,给药后血药浓度迅速下降,血和组织中的药物浓度达有效水平仅维持数小时,这种给药方案
Penicillins are β-lactam antibiotics, the aqueous solution is not stable, at room temperature (25 ℃), 24h within about half of drug cleavage. Along with it, not only the antibacterial effect is obviously reduced, but also the degradation products enter into the human body and bind with the protein, causing a series of immune reactions and the incidence of allergic reactions is significantly increased. Therefore, the daily dose of glucose and other solutions into the slow intravenous infusion, obviously not appropriate. If intramuscular injection of a dose of 1 times a day, or intravenous infusion in a short time, although the above defects can be avoided, but most of the penicillin species half-life is very short, about 1h, after administration of plasma concentration decreased rapidly, blood and The drug concentration in the tissue reaches an effective level for only a few hours and this dosing regimen