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目的 通过观察吸入丁地去炎松 (普米克 )治疗前后哮喘患儿痰中IL 8水平的变化 ,评价此种疗法对气道炎症的影响。方法 对 19例年龄在 5～ 14岁之间哮喘患儿 ,分别于首次就诊和吸入丁地去炎松治疗两周时 ,两次进行取痰检测和病情评价。结果 哮喘发作期患儿经吸入丁地去炎松治疗两周后 ,痰中IL 8水平显著下降 ,呼气峰流速 (PEF)占预计值百分比也有显著改善 (P <0 .0 1) ;且PEF改善率与其痰液IL 8水平下降呈正相关 (P<0 .0 1)。结论 丁地去炎松对哮喘患儿症状及其气道炎症指标有显著改善作用 ,对控制哮喘的炎症疗效肯定
Objective To evaluate the effect of this therapy on airway inflammation by observing the changes of IL 8 levels in sputum of asthmatic children before and after inhalation of triptolide (PUMIC). Methods Twenty-nine children with asthma aged 5 to 14 years old were enrolled in this study. The sputum was taken and the condition was evaluated twice during the first visit and two weeks after the inhalation of triamcinolone. Results The levels of IL 8 in sputum were significantly decreased in the asthmatic children after two weeks of inhalation of D, Q and M, and the percentage of predicted peak expiratory flow rate (PEF) was also significantly improved (P <0.01). There was a positive correlation between PEF improvement rate and sputum IL 8 level (P <0.01). Conclusion Dandu to pineal asthma in children with symptoms and their indicators of airway inflammation significantly improve the role of inflammation in the control of asthma certainly