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三七绒根提取物(76017)为三七绒根乙醇提出物的有效成分,毒性较低,给小白鼠静注LD_(50)为836±17mg/kg。 给麻醉猫静注76017 25～50 mg/kg,3～5分钟内冠脉流量最高增加79％(P<0.05),血压呈暂时性下降,心率也略减慢,心肌耗氧量减少,比给药前平均降低24.3％(P<0.05)。 在家兔离体心脏灌流实验中,当2％76017 0.1和0.2ml注入灌流系统时,小剂量组给药后1分钟,冠脉流量平均增加17.5％;大剂量组给药后5分钟和7.5分钟分别增加48％和43％,(P<0.05),心率也稍减慢(P>0.05)。小剂量组心肌收缩振幅在5分钟内最高增加48％(P<0.05)。 在家兔离体器官血管灌流的实验中,当2％76017 0.1和0.2ml注入灌流系统,记录5分钟内的峰值,小剂量组兔肾、耳及后肢的流量分别增加50,57和32％;而大剂量组分别增加70,64和33％。
Sanjian velvetleaf root extract (76017) is the active ingredient of the ethanol extract of Sanxian velvet root, with low toxicity. The LD_ (50) of mice was intravenously injected with 836 ± 17mg / kg. Anesthetic cat intravenous 76017 25 ~ 50 mg / kg, within 3 to 5 minutes, coronary flow increased by 79% (P <0.05), a temporary decrease in blood pressure, heart rate also slowed slightly, myocardial oxygen consumption decreased, the ratio The average decrease of 24.3% before administration (P <0.05). In the rabbit heart perfusion experiment, when 2% 76017 0.1 and 0.2ml were injected into the perfusion system, the coronary flow increased by 17.5% at an average of 17.5% in the low-dose group 1 minute after administration; in the high-dose group 5 and 7.5 minutes after the administration (P <0.05), heart rate also slowed down slightly (P> 0.05). The amplitude of myocardial contractions in the low-dose group increased by 48% within 5 minutes (P <0.05). In the experiment of ex vivo organ perfusion in rabbits, the peak value in 5 minutes was recorded when 2% of 76017 0.1 and 0.2ml were injected into the perfusion system. The flow of kidney, ear and hindlimb of small dose group increased by 50, 57 and 32% respectively While the high-dose group increased by 70, 64 and 33% respectively.