麦角碱及其衍生物有多种神经内分泌药理活性,目前临床应用者已逾十种,其中最受重视的是1968年由瑞士山道士Fluckiger等研制的溴麦角隐亭。在欧、美、日本及澳大利亚等很多国家进行十余年的临床研究表明,它是神经内分泌药物领域内取得的一项重大进展。一、制备和性质溴麦角隐亭(2-Bromo-α-ergocriptine;Bromocriptine)为肽麦角碱麦角隐亭经溴化成盐而得。麦角隐亭为D-麦角酸与一环状三 Ergot and its derivatives have a variety of neuroendocrine pharmacological activity, there are currently more than 10 clinical applications, of which the most important is bromocriptine developed in 1968 by Flukeiger, Switzerland. More than a decade of clinical research in many countries including Europe, the United States, Japan and Australia has shown that it is a significant advance in the field of neuroendocrine drugs. First, the preparation and nature Bromocriptine (Bromocriptine) Bromocriptine is a peptide ergot ergocryptine bromide derived salt. Ergocrypt for D-lysergic acid and a ring three