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目的：探讨星形细胞瘤（ＡＳＡ）细胞谱系型别及其与生物学行为和病理学分级的关系。方法：免疫组化方法６０例人脑ＡＳＡ的Ａ２Ｂ５、ＧＦＡＰ及ＧＣ抗原表达和谱系分型。结果：４５例ＡＳＡ为１型谱系星形细胞瘤（Ｔ１ＬＡ）；１５例ＡＳＡ含较高密度的Ａ２Ｂ５＋细胞。为２型谱系星形细胞瘤（Ｔ２ＬＡ）。复发性肿瘤Ａ２Ｂ５标记指数显著高于非复发性病例，而ＧＦＡＰ标记指数呈现相反的结果。Ｔ２ＬＡ复发率显著高于Ｔ１ＬＡ（Ｐ＜０．０２）。１２例ＡＳＡ含有低密度的ＧＣ＋细胞。结论：Ｔ１ＬＡ比Ｔ２ＬＡ常见；以Ａ２Ｂ５和ＧＦＡＰ对ＡＳＡ进行谱系分型，有利于其诊断和复发性估计。ＧＣ标记利于识别星形－少枝混合性胶质细胞瘤。
Objective: To investigate the phylotype of astrocytoma (ASA) cells and its relationship with biological behavior and pathological grade. Methods: The immunohistochemical method of 60 cases of human brain ASA A2B5, GFAP and GC antigen expression and pedigree classification. Results: Forty-five ASAs were type 1 lineage astrocytoma (T1LA); 15 ASAs contained higher density A2B5+ cells. Type 2 lineage astrocytoma (T2LA). The A2B5 labeling index of recurrent tumors was significantly higher than that of non-recurrent cases, and the GFAP labeling index showed the opposite result. The recurrence rate of T2LA was significantly higher than that of T1LA (P<0.02). Twelve ASAs contained low-density GC+ cells. Conclusion: T1LA is more common than T2LA; the phylogenetic typing of ASA with A2B5 and GFAP is helpful for its diagnosis and recurrence estimation. The GC marker facilitates identification of star-branch mixed gliomas.