【摘 要】
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Recently,a paper by Kim et al.[1] in Nature Medicine magazine in January,2013 showed that apelin (also known as APLN) inhibits fibroblast growth factor 2 (FGF2)
【机 构】
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Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China
论文部分内容阅读
Recently,a paper by Kim et al.[1] in Nature Medicine magazine in January,2013 showed that apelin (also known as APLN) inhibits fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) expression to ameliorate pulmonary hypertension by regulating the expression of miR-424 and miR-503.This study revealed the molecular mechanism of apelin in inhibiting the process of pulmonary arterial hypertension (PAH) and discovered the role of apelin in regulating miRNA generation for the first time.miRNA functions in the transcriptional regulation of gene expression to control cellular processes,miRNA is a key regulatory factor of protein expression,but the generation and regulation mechanism of miRNA is still unclear.These novel findings bring us inspiration for further research,especially on the mechanism of miRNA generation.Experiments on revealing endogenous active substance,which regulates the generation of miRNAs or revealing miRNAs that regulate the expression of apelin,may bring more breakthroughs in the future.
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