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宫内营养不良与成年后心血管疾病关系密切。研究显示宫内营养不良可通过干扰胎儿糖、脂代谢、激素水平、重要脏器的发育和功能、调控基因的表达及其表观遗传修饰等多种途径导致胎儿的低出生体质量与物质代谢的改变,增加成年后心血管疾病的发生风险。辅助生殖技术干扰了配子的自然受精过程,改变了胚胎的生长环境,可增加子代出生低体质量的发生率,也存在诱发成年后心血管疾病发生的风险。
Intrauterine malnutrition and adult cardiovascular disease are closely related. Studies have shown that intrauterine malnutrition can lead to low birth weight and substance metabolism in the fetus by interfering with fetal glucose, lipid metabolism, hormone levels, development and function of important organs, regulating gene expression and epigenetic modification Change, increase the risk of cardiovascular disease in adulthood. Assisted reproductive technology interferes with the process of natural fertilization of gametes, altering the embryo’s growth environment, increasing the incidence of low-birth-weight births, and also the risk of developing cardiovascular disease in adulthood.