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目的探讨自身免疫性肝炎合并布鲁菌感染时的临床特征、诊断及其治疗等特点。方法回顾性分析我院确诊的1例自身免疫性肝炎合并慢性布鲁菌感染患者的临床特点、相关指标的检测结果并结合文献报道进行总结。结果患者临床表现缺乏特异性。血培养和血清抗体检测呈阳性,C-反应蛋白(CRP)可见升高而降钙素原(PCT)变化不明显。结论布鲁菌病不能仅从临床表现来鉴别和诊断,更不能因为缺少流行病学资料而否定。自身免疫性肝炎患者的CRP水平对急性炎症的敏感性会降低,但仍可以作为疗效判断的参考指标。应适度增加疗程,定期复查,以更好的控制慢性布鲁菌感染。
Objective To investigate the clinical characteristics, diagnosis and treatment of autoimmune hepatitis associated with Brucella infection. Methods A retrospective analysis of our hospital diagnosed in patients with autoimmune hepatitis and chronic brucella infection in patients with clinical features, the relevant indicators of the test results and combined with the literature to summarize. Results The patient’s clinical manifestations of the lack of specificity. Blood culture and serum antibody tests were positive, C-reactive protein (CRP) was elevated and procalcitonin (PCT) did not change significantly. Conclusion brucellosis can not be identified and diagnosed only from clinical manifestations, but can not be neglected because of lack of epidemiological data. Patients with autoimmune hepatitis CRP levels will reduce the sensitivity of acute inflammation, but can still be used as a reference indicator of efficacy. Should be moderately increased treatment, regular review, in order to better control chronic brucella infection.