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动脉粥样硬化被认为是一种慢性炎症、自身免疫性疾病。热休克因子1(HSF1)在多个组织器官中均有表达,是哺乳动物中调节热休克反应最重要的转录因子,参与调节热休克反应、诱导热休克蛋白(HSPs)的表达。它具有多种生物学功能,不仅能抗炎、抗凋亡、保护缺血心肌细胞、抑制心肌纤维化、参与生长发育过程;而且与动脉粥样硬化亦有紧密关系。该文就HSF1在动脉粥样硬化发生、发展过程中的作用作一综述。
Atherosclerosis is considered a chronic inflammation, autoimmune disease. Heat shock factor 1 (HSF1), which is expressed in many tissues and organs, is the most important transcription factor regulating heat shock response in mammals. It is involved in the regulation of heat shock response and the expression of heat shock proteins (HSPs). It has a variety of biological functions, not only anti-inflammatory, anti-apoptotic, protect ischemic cardiomyocytes, inhibit myocardial fibrosis, involved in the process of growth and development; but also with atherosclerosis are also closely related. This article reviews the role of HSF1 in the development and progression of atherosclerosis.