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初步建立了高脂血症大鼠反复脑缺血再灌流后所致的学习记忆功能障碍模型。通过用水迷宫法、跳台法、避暗法进行测试，分别观察7d、15d、30d的变化。结果表明：高脂血症大鼠脑反复缺血再灌流后可明显造成学习记忆障碍的行为学改变，在第7d时就可出现显著变化，而第15d与第7d相比较差别不显著，第30d与第7d比较则差别非常显著，说明该模型可用于血管性痴呆的发病机理探讨和治疗学研究。
The model of learning and memory dysfunction caused by repeated cerebral ischemia-reperfusion in rats with hyperlipidemia was initially established. Through the water maze method, jumping method, avoid dark method test, respectively, observed 7d, 15d, 30d changes. The results showed that the behavior changes of learning and memory impairment can be obviously caused by repeated ischemia and reperfusion in the brain of hyperlipidemic rats, and there was a significant change on the 7th day, while there was no significant difference between the 15th and the 7th days. 30d and 7d compared the difference is very significant, indicating that the model can be used for the pathogenesis of vascular dementia and therapeutic research.