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发展了乙基锌对原位产生的不饱和亚胺的对映选择性共轭加成,磺酰吲哚衍生物在乙基锌存在下原位生成不饱和亚胺,手性亚磷酰胺配体-铜络合物催化二乙基锌对该原位产生的不饱和亚胺反应以最高99%的产率和80%的对映选择性得到了一系列3位取代的光学活性的吲哚衍生物.
The enantioselective conjugate addition of ethylzinc to the unsaturated imines produced in situ was developed. Sulfonylindole derivatives formed in situ in the presence of ethylzinc an unsaturated imine, chiral phosphoramidite The bulk-copper complex catalyzes the reaction of diethylzinc on this in situ generated unsaturated imine to give a series of 3-substituted optically active indoles with up to 99% yield and 80% enantioselectivity derivative.