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在人类辅助生殖中,经促排卵体外获得的卵母细胞中,有滑面内质网聚集体(smooth endoplasmic reticulum clusters,sERC)形成者占有一定比例。这些卵母细胞最终发展为非整倍体的比例较高,影响随后的胚胎发育和妊娠结局。近年来研究显示:卵母细胞胞质内sERC的形成与多种因素相关,主要是Ca2+浓度变化的影响。大多数学者认为卵母细胞sERC的形成会导致受精率、卵裂率和囊胚形成率降低及胚胎质量的下降,使得妊娠率显著降低;然而,也有多项报道已证实含sERC的卵母细胞可以正常受精并获得后代。因此对于那些临床助孕治疗中获得sERC+胚胎或者胚胎数目不足的患者,移植sERC+胚胎或sERC+/sERC-胚胎不失为胚胎移植的一个选择。
In human assisted reproduction, oocytes obtained from ovulation in vitro have a proportion of the formation of smooth endoplasmic reticulum clusters (sERC). The higher proportion of these oocytes that eventually develop aneuploidy affects subsequent embryonic development and pregnancy outcomes. In recent years, studies have shown that: the formation of oocyte cytoplasmic sERC and a variety of factors, mainly Ca2 + concentration changes. Most scholars believe that the formation of oER sERC will lead to fertilization rate, cleavage rate and blastocyst formation rate decreased and the decline in the quality of embryos, making the pregnancy rate decreased significantly; however, there are a number of reports have confirmed that oocytes containing sERC Fertilize normally and get offspring. Transplantation of sERC + embryos or sERC + / sERC-embryos is therefore an option for embryo transfer in those patients who have acquired sERC + embryos or have an insufficient number of embryos during clinical pregnancy therapy.