论文部分内容阅读
[目的]系统评价甲胎蛋白(AFP)联合甲胎蛋白异质体L3(AFP-L3)在原发性肝癌(HCC)中的诊断价值。[方法]计算机检索国内外重要数据库,依据纳入和排除标准筛选文献,运用诊断试验准确性质量评价工具(QUADAS)评价纳入文献的质量。数据采用Meta-DiSc1.4和SPSS 19.0软件进行统计分析。[结果]共纳入9篇文献,AFP联合AFP-L3检测原发性肝癌的合并敏感度、合并特异度、阳性似然比、阴性似然比、诊断优势比分别为:0.635(0.602,0.667),0.854(0.836,0.871),4.933(3.731,6.523),0.308(0.212,0.449),19.805(10.497,37.367)。SROC曲线下面积0.9101,Q指数为0.8422。[结论]AFP联合AFP-L3检测原发性肝癌有一定诊断价值,可作为重要的筛选指标,但仍需要更多高质量、大样本、多中心的研究加以论证。
[Objective] To evaluate the diagnostic value of AFP-AFP-L3 in primary hepatocellular carcinoma (HCC). [Methods] The computer was used to search important databases at home and abroad, select the literature according to inclusion and exclusion criteria, and evaluate the quality of the included documents by using QUADAS (Diagnostic Test Accuracy Quality Evaluation Tool). Data were statistically analyzed using Meta-DiSc 1.4 and SPSS 19.0 software. [Results] A total of 9 articles were included in this study. The combined sensitivity, combined specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of AFP combined with AFP-L3 were 0.635 (0.602,0.667) , 0.854 (0.836, 0.871), 4.933 (3.731, 6.523), 0.308 (0.212, 0.449), 19.805 (10.497, 37.367). The area under the SROC curve was 0.9101 and the Q-index was 0.8422. [Conclusion] AFP combined with AFP-L3 in the diagnosis of primary liver cancer has some diagnostic value, which can be used as an important screening index, but more high-quality, large sample and multicenter studies are needed.