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猫在氯醛糖,乌拉坦混合腹腔麻醉下,通过立体定向仪,用微量注射器将γ-氨基丁酸(GABA)拮抗剂印防已毒素(Picrotoxin,PT)注入侧脑室(30μl,0.5μg/μl),观察心肌收缩力和肾交感神经活动的变化。结果表明侧脑室注入PT,不仅血压,心率明显增加,而且心肌收缩力和肾交感神经活动明显加强,并且量-效之间存在显著的正相关关系。本实验还观察了压力反射对PT引起的心血管反应的影响。结果表明当缓冲神经去除后,侧脑室注入PT所引起的上述指标增加明显大于缓冲神经完整情况的效应。以上结果提示:(1)这些活动的改变与GABA系统的活动有关;(2)脑内的GABA系统阻断后引起的心血管反应并不是由压力反射造成的,压力反射只是部分地压制了其心血管兴奋作用。
Cats were anesthetized with chloralose and urethane, and injected into the lateral ventricle (30μl, 0.5μg / ml) by a stereotactic instrument with a microinjector using GABA antagonist Picrotoxin (PT) μl) to observe changes of myocardial contractility and renal sympathetic nerve activity. The results showed that lateral ventricle injection of PT, not only blood pressure, heart rate increased significantly, and myocardial contractility and renal sympathetic nerve activity was significantly enhanced, and the amount of - There was a significant positive correlation between effect. The experiment also observed the impact of stress reflex on the cardiovascular response caused by PT. The results show that when the buffer after nerve removal, lateral ventricle injection of PT caused by the above indicators increased significantly greater than the complete effect of the buffer nerve. The above results suggest that: (1) changes in these activities are related to the activity of the GABA system; (2) cardiovascular responses to blockage of the GABA system in the brain are not caused by stress reflexes that partially suppress Cardiovascular excitement.