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股骨头坏死属于中医骨蚀范畴,为骨科难治病,中医以活血化瘀、益气通络、扶正祛邪为主要治则,根据此治则研制而成的中成药马氏骨片1号主要药效学表明,该药有止痛、抗炎作用,能够提高机体的免疫机能,并能改善“阳虚证”小鼠生殖器官萎缩、重量减轻等症状,对实验性大鼠股骨骨质疏松的骨密度下降、骨钙、磷含量降低等有治疗作用,股骨磨片组织学检查证实,骨质疏松所致股骨头部位骨小梁宽度变细、小梁空隙增大等病变亦有改善。
Femoral head necrosis belongs to the category of osteoporosis in traditional Chinese medicine. It is an orthopedic refractory disease, and traditional Chinese medicine is mainly used for promoting blood circulation, removing blood stasis, relieving qi and resolving evil, and according to this rule, the Chinese medicine Ma’s bone fragment 1 was developed. The main pharmacodynamics show that the drug has analgesic and anti-inflammatory effects, can improve the body’s immune function, and can improve the “yang-deficiency” mice reproductive organs, atrophy, weight loss and other symptoms, the experimental rat femoral osteoporosis The decrease in bone mineral density, bone calcium, and phosphorus content have a therapeutic effect. Histological examination of the femur bone plate confirmed that osteoporosis caused a reduction in the width of the trabecular bone at the femoral head and an increase in trabecular space.