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本文探讨毛冬青甲素作用于血管运动中枢而使血压降低的机理。结果显示:SD 大鼠(n=51)侧脑室微量注射毛冬青甲素(1g/L,20μl),可使平均动脉血压下降23％,此降压效应可被酚妥拉明完全阻断;毛冬青甲素还具有类似心得安阻断β受体的作用。结果证明毛冬青甲素可影响心血管中枢兴奋性,通过神经调节机制改变外周血管平滑肌紧张性。
This article discusses the mechanism of the lowering of blood pressure by Mao Dongqing A on the vasomotor center. The results showed that microinjection of oxyphylline (1 g/L, 20 μl) into the lateral ventricle of SD rats (n=51) reduced the mean arterial blood pressure by 23%. This hypotensive effect was completely blocked by phentolamine. Mao Dong Qing Jia Su also has a similar propranolol block β receptor role. The results demonstrated that Mao Dongqing A can affect the central nervous excitability, through the neuromodulation mechanism to change the peripheral vascular smooth muscle tone.