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目的探讨胎粪吸入综合征(MAS)与婴幼儿喘息的关系。方法对2003年1月至2007年1月在我院住院的64例MAS患儿随访1年,观察其喘息的发病情况、特应性体质的表现及生后家庭成员是否有吸烟者,同时进行食物过敏原、吸入过敏原筛查及肺炎支原体抗体(MP-IgM)检测,并与对照组比较,分析MAS与早期婴幼儿喘息的相关性。结果MAS患儿婴幼儿喘息的发生率为25.0%,显著高于对照组7.5%(P<0.01);重度MAS婴幼儿喘息的发生率显著高于轻度MAS(P<0.05);两组中有特应性体质的比较差异无统计学意义(P>0.05);生后家庭成员中有吸烟者比较差异无统计学意义(P>0.05);两组发生喘息的患儿中食物过敏原、吸入性过敏原筛查阳性率及MP-IgM阳性率比较差异均无统计学意义(P>0.05)。结论早期婴幼儿喘息的发病与MAS密切相关,并与其轻重程度有关;MAS疾病本身可能导致喘息,建议有针对性地进行早期干预。
Objective To investigate the relationship between meconium aspiration syndrome (MAS) and wheezing in infants and young children. Methods Sixty-four patients with MAS who were hospitalized in our hospital from January 2003 to January 2007 were followed up for one year to observe the incidence of wheezing, the manifestation of atopic constitution and the presence of smokers in their family members after birth Food allergens, inhalation allergen screening and Mycoplasma pneumoniae antibody (MP-IgM) test, and compared with the control group, analysis MAS and early infants wheezing correlation. Results The incidence of wheezing in children with MAS was 25.0%, significantly higher than that in the control group (P <0.01). The incidence of wheezing in severe MAS was significantly higher than that in mild MAS (P <0.05) There was no significant difference in atopic constitution (P> 0.05). There was no significant difference in smoking among family members after birth (P> 0.05). Food allergens, There were no significant differences in the positive rate of inhalational allergen screening and the positive rate of MP-IgM (P> 0.05). Conclusions The incidence of wheezing in infancy and early childhood is closely related to MAS, which is related to the severity of asthma. MAS disease itself may cause wheezing, and it is suggested that early intervention should be targeted.