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目的探讨p63在结直肠癌中表达情况及其预后价值。方法采用免疫组化方法检测66例结直肠癌患者癌组织中p63的表达情况。分析p63的表达与临床病理因素相关性及对无进展生存期(PFS)和总生存(OS)的影响。结果 66例结直肠癌患者中,31例(47%)p63高表达,35例(53%)低表达。p63与癌周结节有关(P=0.021)。p63低表达组和高表达组的5年OS分别是49%和74%(P<0.001),5年PFS两组分别是44%和71%(P<0.001)。单因素与多因素分析显示p63的表达是结直肠癌独立的预后因素(P=0.035)。结论结直肠癌组织中p63与癌周结节呈负相关,与OS和PFS呈正相关,p63可作为结直肠癌独立预后因素。
Objective To investigate the expression of p63 in colorectal cancer and its prognostic value. Methods Immunohistochemistry was used to detect the expression of p63 in 66 cases of colorectal cancer. The relationship between the expression of p63 and clinicopathological factors and the progression-free survival (PFS) and overall survival (OS) were analyzed. Results Of the 66 patients with colorectal cancer, 31 (47%) had high expression of p63 and 35 (53%) had low expression. P63 was associated with cancer nodules (P = 0.021). The 5-year OS was lower in the p63 group than in the high-expression group (49% vs 74%, P <0.001), while the 5-year PFS was 44% and 71%, respectively. Univariate and multivariate analysis showed that p63 expression was an independent predictor of colorectal cancer (P = 0.035). Conclusions The expression of p63 in colorectal cancer is negatively correlated with the tumor nodules and positively correlated with OS and PFS. P63 can be used as an independent prognostic factor for colorectal cancer.