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采用微量稀释法测定了 (S) 9 氟 2 ,3 二氢 3 甲基 10 ( 4 ( 2 嘧啶 ) 1 哌嗪基 ) 7 氧代 7H 吡啶并 [1,2 ,3 de] [1,4]苯并口恶嗪 6 羧酸 (YH 7)等氟喹诺酮及大环内酯类、四环素类抗生素对人型枝原体 (Mh)、口腔枝原体 (M .ora)、唾液枝原体 (M .sal)、解脲枝原体 (Uu)的体外敏感性。结果显示 :YH7对Mh、M .ora、M .sal、Uu的最低抑制浓度 (MIC)分别为 0 5、0 2 5、0 12 5、0 12 5mg/L。它的抑菌活性是氧氟沙星 2～ 16倍 ,与红霉素、柱晶白霉素相当。Mh、Uu对YH7及交沙霉素不易产生诱导耐药性 ,而对红霉素和四环素易产生诱导耐药性。而对红霉素或四环素产生耐药的Mh和Uu菌株对红霉素和四环素交叉耐药而对YH7和交沙霉素无交叉耐药。
(S) 9 fluoro 2, 3 dihydro 3 methyl 10 (4 (2 pyrimidine) 1 piperazinyl) 7 oxo 7H pyrido [1,2,3- de] [1,4] Fluoroquinolones and macrolides such as benzoxazine 6 carboxylic acid (YH 7) and tetracycline antibiotics were effective against human M, M, .sal), in vitro sensitivity of Ureaplasma urealyticum (Uu). The results showed that the minimum inhibitory concentrations (MICs) of YH7 against Mh, M. ora, M.sal and Uu were 0 5,025, 0 12 5 and 0 12 5 mg / L, respectively. Its antibacterial activity is ofloxacin 2 to 16 times, with erythromycin, levamisole quite. Mh, Uu on YH7 and jasminemycin not easy to induce resistance, but erythromycin and tetracycline susceptibility to induce resistance. The strains Mh and Uu resistant to erythromycin or tetracycline were cross-resistant to erythromycin and tetracycline and no cross-resistance to YH7 and jasmomycin.