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血管生成素样蛋白4是新发现的一种分泌型蛋白,它与血管生成、脂类代谢、葡萄糖代谢密切相关。新的研究发现,ANGPTL4被水解后形成的片段在不同的组织和环境中表现出不同的生理功能,这些片段可能是肿瘤生长、侵袭和转移过程中重要的调节因子。本文就ANGPTL4的生物学特性、其在肿瘤生长、转移中的可能作用以及潜在的临床应用价值做一综述。
Angiogenin-like protein 4 is a newly discovered secreted protein that is closely related to angiogenesis, lipid metabolism and glucose metabolism. The new study found that the fragments formed after hydrolysis of ANGPTL4 showed different physiological functions in different tissues and environments, and these fragments may be important regulators of tumor growth, invasion and metastasis. This review summarizes the biological characteristics of ANGPTL4, its possible role in tumor growth and metastasis, and its potential clinical value.