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目的观察血液灌流+连续性静脉血液滤过(CVVH)对急性胰腺炎的治疗效果。方法选取医院重症急性胰腺炎(SAP)患者20例,采用常规治疗加血液灌流+CVVH治疗,比较治疗前后的各项指标和治疗效果。结果治愈16例,治愈率80.0%。患者治疗后血清学指标和细胞因子较治疗前均改善,所有患者的酸碱失衡和电解质紊乱均纠正。患者治疗后急性生理评分(APACHEII)及多器官功能障碍(MODS)评分均较治疗前降低,差异均有统计学意义(P<0.05)。结论血液灌流+CVVH对治疗急性胰腺炎患者的临床疗效显著,可有效减轻炎性反应,恢复血液灌流,防治器官损伤,治愈率高,预后好,值得临床推广。
Objective To observe the therapeutic effect of hemoperfusion + continuous venous hemofiltration (CVVH) on acute pancreatitis. Methods Twenty patients with severe acute pancreatitis (SAP) in hospital were selected and treated with conventional therapy plus hemoperfusion + CVVH. The indexes before and after treatment were compared. The results were cured in 16 cases, the cure rate was 80.0%. Serum markers and cytokines in patients after treatment were improved compared with those before treatment, acid-base imbalance and electrolyte imbalance were corrected in all patients. APACHEII scores and MODS scores of patients after treatment were lower than those before treatment, the differences were statistically significant (P <0.05). Conclusion Hemoperfusion + CVVH is effective in treating acute pancreatitis. It can effectively reduce the inflammatory reaction, restore the blood perfusion and prevent organ damage. The cure rate is high and the prognosis is good. It is worthy of clinical promotion.