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组织因子作为FⅦ/FⅦa的细胞膜表面受体,是外源性凝血系统的关键因子,组织因子通过介导凝血激活形成血栓。动脉粥样硬化斑块破裂处血栓形成是急性冠脉综合征的主要原因,其临床后果的严重性决定于血栓的范围和进展。急性冠脉综合征时循环单核细胞和微颗粒表达组织因子,促进全身的促凝活性。动脉粥样硬化斑块中巨噬细胞、平滑肌细胞、血管内皮细胞表达组织因子,不稳定性斑块中组织因子表达和活性较稳定性斑块更高。组织因子通路抑制物是内源性组织因子抑制物,对调剂血栓形成有重要作用。现就目前组织因子与急性冠脉综合征研究进展作一综述。
Tissue factor, the membrane-surface receptor of FⅦ / FⅦa, is a key factor in the extrinsic coagulation system through which tissue factor mediates clot activation. Thrombosis at the rupture of atherosclerotic plaques is a major cause of acute coronary syndrome and the severity of its clinical consequences depends on the extent and progression of the thrombus. Circulating monocytes and microparticles express tissue factor during acute coronary syndromes and promote systemic procoagulant activity. In atherosclerotic plaque, macrophages, smooth muscle cells and vascular endothelial cells express tissue factor, and the expression and activity of tissue factor in unstable plaque are higher than those in stable plaque. Tissue factor pathway inhibitor is an inhibitor of endogenous tissue factor, the regulation of thrombosis have an important role. Now on the current tissue factor and research progress of acute coronary syndrome are reviewed.