A practical optical fiber differential pressure sensor is presented at first. Then the techniques of light source feedback, set up of reference channel, proportional measurement and other methods to improve the stability of the system as well as to reduce the interference with same nature are emphatically discussed. Finally, the experiment results of the developed instrument are given. A practical optical fiber differential pressure sensor is presented at first. Then the techniques of light source feedback, set up of reference channel, proportional measurement and other methods to improve the stability of the system as well as to reduce the interference with same nature are emphatically discussed. Finally, the experiment results of the developed instrument are given.