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目的 :研究肝硬化合并原发性肝癌、原发性肝癌、肝硬化及正常人血清转化生长因子 -α(transforminggrowth factor- α,TGF- α)变化 ,探讨 TGF- α在肝硬化合并原发性肝癌中的临床意义。方法 :肝硬化合并原发性肝癌48例 ,原发性肝癌 30例 ,肝硬化 80例 ,正常对照组 5 0例 ,采用放免法检测血清 TGF- α。结果 :血清 TGF- α含量在肝硬化合并原发性肝癌时明显高于肝硬化组及正常对照组 ,P <0 .0 1;原发性肝癌血清 TGF- α含量明显高于肝硬化及正常对照组 ,P <0 .0 1;肝硬化合并原发性肝癌血清 TGF-α含量与原发性肝癌血清 TGF-α含量无显著差异 ,P >0 .0 5。结论 :血清 TGF-α含量在肝硬化合并原发性肝癌及原发性肝癌时均明显增高 ,因此 TGF-α血清含量测定是诊断原发性肝癌 ,特别是肝硬化合并原发性肝癌的有价值的标志物。
Objective: To study the changes of serum transforming growth factor-α (TGF-α) in patients with primary liver cancer, primary liver cancer, cirrhosis and normal liver cirrhosis, and to explore the role of TGF-α in the pathogenesis of cirrhosis complicated with primary Clinical Significance of Liver Cancer. Methods: Forty-eight patients with cirrhosis complicated with primary hepatocellular carcinoma, 30 primary hepatocellular carcinoma, 80 cirrhosis and 50 normal control group were measured by radioimmunoassay. Serum TGF-α was detected by radioimmunoassay. Results: The serum level of TGF-α in cirrhosis with primary liver cancer was significantly higher than that in cirrhosis and normal controls (P <0.01). The serum level of TGF-α in primary liver cancer was significantly higher than that in cirrhosis and normal Control group, P <0.01; serum TGF-α content in cirrhosis complicated with primary liver cancer was not significantly different from that in primary liver cancer (P> 0.05). Conclusion: The serum level of TGF-α in cirrhosis with primary hepatocellular carcinoma and primary hepatocellular carcinoma were significantly higher, so the serum TGF-α level is the diagnosis of primary liver cancer, especially in cirrhosis with primary liver cancer A symbol of value