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2-Aminocyclopenta[d]pyrimidines 3a–c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride(1:2:1 molar ratio). Also, cyclization of 2,5-bis-(arylmethylidene)cyclopentanones 2 with guanidine hydrochloride(1:1 molar ratio) in methanol in the presence of sodium methoxide afforded cyclopenta-[d]pyrimidines 3. Compound 3c has been shown to be a useful building block for the synthesis of some novel pyrimido[1,2-a]pyrimidines 5, 7and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data.
2-Aminocyclopenta [d] pyrimidines 3a-c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride (1: 2: 1 molar ratio) - (arylmethylidene) cyclopentanones 2 with guanidine hydrochloride (1: 1 molar ratio) in methanol in the presence of sodium methoxide afforded cyclopenta- [d] pyrimidines 3. Compound 3c has been shown to be useful building block for the synthesis of some novel pyrimido [1,2-a] pyrimidines 5, 7 and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data.