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本文采用微量滴定法比较了11种内酰胺类和氨基糖苷类抗生素对134株需氧菌的体外抗菌活性。试验菌均由临床新近分离而得。实验结果表明头孢菌素Ⅰ、羟苄四唑头孢菌素和氨基糖苷类抗生素(艮他霉素、丁胺卡那霉素和双脱氧卡那霉素)对金葡菌的活性最强,MIC_(50)<0.5μg/ml。噻吩甲氧头孢菌素和第三代头孢菌素(羟羧氧头孢菌素Ly_(127935),氨噻肟头孢菌素HR_(756)和氧哌羟苯唑头孢菌素T_(1551))对金葡菌的MIC_(50)为2～16μg/ml;对耐新青霉素Ⅰ的金葡菌活性更差,
In this paper, the microtiter method was used to compare the antibacterial activity of 11 lactam and aminoglycoside antibiotics against 134 aerobic bacteria in vitro. Test bacteria are newly isolated from the clinical. The experimental results show that the cephalosporin Ⅰ, cephalosporin and aminoglycoside antibiotics (gentamycin, amikacin and dideoxykanamycin) on Staphylococcus aureus activity strongest, MIC_ (50) <0.5 μg / ml. Thiophene methoxy cephalosporins and the third generation cephalosporins (oxycarbosil Ly_ (127935), cefotaxime cephalosporin HR_ (756) and oxyphencyclohexidine cephalosporin T_ (1551)) pairs Staphylococcus aureus MIC_ (50) of 2 ~ 16μg / ml; resistant to new penicillin Ⅰ Staphylococcus aureus activity worse,