论文部分内容阅读
心肌细胞和血管内皮细胞均有合成醛固酮的能力,特别是在心力衰竭、心肌梗死等病理状态下,醛固酮合成明显增多。醛固酮对心脏的作用主要是诱导心肌纤维化、冠状动脉周围的血管炎症、内皮功能障碍,加速氧化应急反应,心脏的电生理作用,使钠-钾泵功能下降,最终导致动脉粥样硬化、心脏重构、心力衰竭、心律失常。众多研究发现,在冠心病及高血压患者中醛固酮水平明显升高,且与预后相关。抗醛固酮治疗能降低心肌梗死并心力衰竭患者的病死率,防止血管纤维化,抑制心脏重构,改善心功能。
Cardiomyocytes and vascular endothelial cells have the ability to synthesize aldosterone, especially in heart failure, myocardial infarction and other pathological conditions, aldosterone synthesis increased significantly. The main role of aldosterone on the heart is to induce myocardial fibrosis, vascular inflammation around the coronary arteries, endothelial dysfunction, accelerated oxidation of the emergency response, the electrophysiological effects of the heart, so that sodium-potassium pump function decreased, eventually leading to atherosclerosis, heart Reconstruction, heart failure, arrhythmia. Many studies have found that in patients with coronary heart disease and hypertension aldosterone levels were significantly increased, and with the prognosis. Anti-aldosterone treatment can reduce mortality in patients with myocardial infarction and heart failure, prevent vascular fibrosis, inhibit cardiac remodeling and improve cardiac function.