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目的 探讨正常眼压青光眼 (NPG)患者HRT -Ⅱ检查的临床特征 ,分析HRT -Ⅱ视乳头立体测量指标的变量分类、相互关系和临床病理意义 ,评价不同指标的诊断性能 ,简化指标体系。方法 对两组NPG患者 (5 3例 )和一组正常受试者 (2 2例 )进行HRT -Ⅱ检查 ,对HRT -Ⅱ推荐的盘沿面积 (RA )、盘沿容积 (RV )、视杯形状测度 (CSM )、轮廓线高度变异 (HVC)和视网膜神经纤维层平均厚度 (RNFLT)等 5项指标和本文提出的视杯容积指数 (CVI)及其有关的视杯容积 (CV )、视盘面积 (DA)和视杯平均深度 (MCD)等 4项指标进行分组间和指标间的比较 ,对指标体系及其正常范围做临床病理意义和正态分布理论的分析 ,对不同指标做诊断性能的评价。结果 NPG组在CSM、RA、RNFLT、RV、MCD、CV和CVI上与正常组间差异有显著性 (P <0 0 1,F =10 0 0～ 3 7 77) ,其中CSM、RA、RV、MCD和CVI的差异出现于早期患者组 (P <0 0 5 ,Q =3 5 0或P <0 0 1,Q =4 13～ 12 2 1)。各指标在变量关系上被分为基础变量和导出变量 ,在临床意义上除视盘面积可视作双侧指标外 ,其余指标均为单侧有意义指标 ,仪器提供的“正常范围”的显著性水平分别为 0 3 173和 0 15 86。CVI是一包含 5个变量的复合指标 ,其诊断性能仅次于CSM。结论 NPG患者在HRT -
Objective To investigate the clinical features of HRT-Ⅱ in patients with normal tension glaucoma (NPG) and to analyze the variable classification, correlation and clinicopathological significance of stereotactic indexes of HRT-Ⅱ optic disc, evaluate the diagnostic performance of different indexes and simplify the index system. Methods Two groups of NPG patients (53 cases) and a group of normal subjects (22 cases) were examined by HRT-II. HRT-II recommended platelet area (RA), plate rim volume (RV) CSM, HVC and RNFLT, and the cup volume index (CVI) and the related cup volume (CV) in this paper, Optic disc area (DA) and optic disc average depth (MCD) were compared between groups and indicators, the index system and its normal range of clinical pathological significance and normal distribution theory analysis, diagnosis of different indicators Performance evaluation. Results There was significant difference between CSG, RA, RNFLT, RV, MCD, CV and CVI in NPG group and normal group (P 0 01, F 0 0 0 3 7 77) The differences between MCD and CVI occurred in the early stage of patients (P <0.05, Q = 350 or P <0.01, Q = 413-1312). Each index is divided into the basic variable and the derived variable in the variable relationship. In the clinical sense, except the optic disc area can be regarded as the bilateral index, the other indexes are all unilateral significant indexes. The “normal range” significance provided by the instrument The levels were 0 3 173 and 0 15 86 respectively. CVI is a composite of 5 variables with diagnostic performance second only to CSM. Conclusion NPG patients in HRT -