论文部分内容阅读
目的 探讨广州地区小儿上消化道疾病中幽门螺杆菌 (H .pylori)感染的临床状况与组织学特点。方法 对 1994～ 2 0 0 1年广州市儿童医院 374 2例患上消化道疾病患儿采用日产奥林巴斯GIF PQ2 0纤维胃镜和富士能EG 4 5 0PE电子胃镜检查 ,并取胃窦部黏膜进行病理学检查及快速尿素酶试验 ,13 C 呼气试验检测。结果 胃镜检查病变检出率 94 4 4 % (35 34/ 374 2 ) ,其中H .pylori感染检出率占 18 14 % (6 4 1/ 35 34)。各年龄组胃十二指肠疾病H .pylori感染率具有显著差别 (P =0 0 0 0 1) ,H .pylori感染与年龄呈显著正相关 (r =0 914 ,P =0 0 0 0 1)。H .pylori感染前三位疾病是慢性浅表性胃炎、十二指肠球炎、十二指肠球部溃疡 ,其中结节性改变占十二指肠球炎的 4 7 5 7% (98/ 2 0 6 )。随着年龄的增长 ,上消化道疾病的发生率逐渐升高 (r =0 994 ,P =0 0 0 3)。消化性溃疡的发生率亦随年龄增长而增加 (十二指肠溃疡 :r =0 976 ,P =0 0 12 ;胃溃疡 :r =0 917,P =0 0 4 3)。H .pylori感染病例中组织学显示中 重度慢性胃炎占 82 97% (190 / 2 2 9)。结论 小儿H .pylori感染率随年龄增长而递增 ,胃、十二指肠黏膜结节性改变是小儿H .pylori感染的胃镜下特征。广州地区H .pylori感染有异于国内外其
Objective To investigate the clinical and histological features of Helicobacter pylori infection in children with upper gastrointestinal diseases in Guangzhou. Methods A total of 3742 patients with upper gastrointestinal diseases in Guangzhou Children’s Hospital from 1994 to 2001 were examined with Nissl Olympus GIF PQ20 fiber endoscopy and Fujinon EG450PE electron gastroscopy. Mucosal pathological examination and rapid urease test, 13 C breath test. Results The detection rate of gastroscopy was 94 4 4% (35 34/374 2), of which the detection rate of H. pylori infection was 18 14% (64 1/35 34). H.pylori infection rate of gastroduodenal disease in each age group was significantly different (P = 0 0 0 0 1), H.pylori infection was positively correlated with age (r = 0 914, P = 0 0 0 0 1 ). H. pylori infection in the first three diseases are chronic superficial gastritis, duodenal inflammation, duodenal ulcer, of which nodular changes accounted for 47.57% of duodenal inflammation (98 / 2 0 6). With age, the incidence of upper gastrointestinal diseases gradually increased (r = 0 994, P = 0 0 0 3). The incidence of peptic ulcer also increased with age (duodenal ulcer: r = 0 976, P = 0 0 12; gastric ulcer: r = 0 917, P = 0 0 4 3). H. Pylori infection histology showed moderate to severe chronic gastritis 82 97% (190/229). Conclusions The prevalence of H.pylori infection in children increases with age. The nodular changes of gastric and duodenal mucosa are gastroscopic features of H.pylori infection in children. H. pylori infection in Guangzhou is different from its home and abroad