AIM:To study the effect of life events,personality and coping strategies on depression of undergraduates.METHOD:Fifteen hundred students were selected in the three schoolyards of Central South University.Life Events Scale,Coping Strategies Scale,Eysenck Personality Questionnaire(EPQ)and Self rating Depressive Scale (SDS) were used to assess all samples.RESULTS:The score of SDS was (42± 8).The life events came from relationship of person,stress of study,loss,punishment,health and adaptation,love and family were higher in the SDS group of higher score,which the SDS group of higher score took more negative coping strategies than the normal score.CONCLUSION:The rate of depression was higher in undergraduates,which need more attention on it.More life events, introversive instability personality and negative coping strategies may be the main risk factors that caused depression.