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本研究结果表明,通胆排石冲剂Ⅰ号(96g/kg)大白鼠十二指肠给药,能明显增加胆汁流量,小白鼠(88g/kg与176g/kg)灌胃给药,能明显增加胆囊重量(含胆汁),证明该剂具有明显的利胆作用。该药能显著抑制冰醋酸所致小白鼠腹腔毛细血管通透性增加和二甲苯所致小白鼠耳肿胀,具有明显的抗炎作用。上述药理作用为通胆排石冲剂Ⅰ号的临床应用提供了部分药理实验依据。
The results of this study indicate that the duodenal administration of Tongdan Paishi I (96g/kg) rats can significantly increase the flow of bile, and the mice (88g/kg and 176g/kg) can be fed. Gastric administration significantly increased gallbladder weight (containing bile), demonstrating that the agent has a clear choleretic effect. The drug can significantly inhibit the increase of peritoneal capillary permeability of mice induced by glacial acetic acid and xylene-induced ear swelling of mice, and has obvious anti-inflammatory effects. The above pharmacological effects provide some pharmacological experimental basis for the clinical application of Tongbiao Paishi Granule I.