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观察了硫酸锌（ＺｎＳＯ＿４）对狗整体肺、脑循环和家兔离休肺内动脉、脑基底劝脉环急性缺氧反应的影响。在整体实验，静脉注射（ｉｖ）硫酸锌１７μｇ·ｋｇ￣(－１)·ｍｉｎ￣(－１)，３０ｍｉｎ后缺氧引起的肺血管阻力的增加值（ΔＰＶＲ）升高；但ｉｖ硫酸锌５０μｇ·ｋｇ￣(－１)·ｍｉｎ￣(－１)后，ΔＰＶＲ降低（Ｐ＜０．０５）。上述剂量硫酸锌对脑血流量及脑血管阻力的缺氧性改变均无显著性影响。在离体血管环实验中，硫酸锌０．１ｍｍｏｌ／Ｌ作用后，内皮完整肺动脉环（ＰＡ￣＋）的缺氧收缩幅度（ＴＩＨ）增加（Ｐ＜０．０５），去内皮肺动脉环（ＰＡ）的ＴＩＨ无显著改变；但在０．３ｍｍｏｌ／Ｌ作用下，ＰＡ￣＋及ＰＡ￣－的ＴＩＨ均降低（Ｐ＜０．０５）。硫酸锌对基底动脉环（ＢＡ￣＋和ＢＡ￣－）缺氧反应无显著影响。结果提示，硫酸锌对血管缺氧反应的影响依剂量大小和血管部位（肺或脑）之不同而异。
The effects of zinc sulfate (ZnSO_4) on the acute pulmonary anoxia in the whole pulmonary and cerebral circulation and in the pulmonary artery and brain base were observed. In the whole experiment, the increase of pulmonary vascular resistance (ΔPVR) caused by hypoxia after intravenous injection (iv) of zinc sulfate 17 μg · kg -1 (-1) · min -1 (30 min) ΔPVR decreased (P <0.05) after treatment with kg ~ (-1) · min ~ (-1). The above dose of zinc sulfate on cerebral blood flow and cerebral vascular resistance hypoxia did not change significantly. In the ex vivo vascular ring test, 0.1 mmol / L of zinc sulfate increased the TIH of intact pulmonary artery rings (PA ~ +) (P <0.05) ) Of TIH no significant change; but 0.3mmol / L, PA ~ + and PA ~ - TIH decreased (P <0.05). Zinc sulphate had no significant effect on hypoxia in basilar artery rings (BA ~ + and BA ~ -). The results suggest that the effect of zinc sulfate on vascular hypoxia varies depending on the dose size and the vascular site (lung or brain).