结节性硬皮病或称瘢痕疙瘩样硬皮病是其一种少见的变型,临床上类似自发的瘢痕疙瘩而发生于进行性系统性硬化病人中,其发病机理尚不清楚。粘胶素(tenascin)是近期发现的一种克隆化的细胞外基质蛋白,被认为是组织再造的一种标记。以往的研究已证明了粘胶素在进行性系统性硬化真皮中呈持久性的中等水平;在硬斑病和增生性瘢痕损害中粘素强阳性但短暂存在。为进一步研究结节性硬皮病的发病机理,作者用免疫反应粘胶素作为一个标记来表达皮损中纤维化活性,对1例40岁的女性结节性硬皮病患者做了研究。在患者胸部急性 Nodular scleroderma, or keloid-like scleroderma, is a rare variant of it. Clinically similar to spontaneous keloids, it occurs in patients with progressive systemic sclerosis and its pathogenesis is unclear. Tenascin, a recently discovered cloned extracellular matrix protein, is considered a marker of tissue remodeling. Previous studies have demonstrated that viscose is at a moderately persistent level in the progressive systemically hardened dermis; in the hard spot and hypertrophic scar lesions the adhesin is strongly positive but transiently present. To further investigate the pathogenesis of nodular scleroderma, the authors used immunoreactive viscose as a marker to express fibrotic activity in lesional lesions, and a 40-year-old woman with nodular scleroderma was studied. Acute in the patient’s chest