土贝母结晶D的抗肿瘤作用,已有报道。本文报告结晶D的急性、亚急性毒性试验结果。急性毒性先用小白鼠进行剂量预试。初试结果表明,肌肉注射全部死亡组剂量为150mg/kg,全部存活剂量25mg/kg。根据初试得出的剂量,共分11组,每组雌雄各5只小鼠,各组分别肌肉给药一次后,观察并记录有 The anti-tumor effect of crystalline Fritillaria D has been reported. This article reports the results of acute, subacute toxicity tests for crystalline D. Acute toxicity was first pre-tested with mice. The results of the initial trial showed that the total dose of death in the intramuscular injection group was 150 mg/kg, and the total survival dose was 25 mg/kg. According to the initial test dose, there are 11 groups, 5 male and 5 female mice in each group. After each group was administered muscle once, observed and recorded