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目的观察介入治疗结合三维适形放疗治疗中晚期肝癌疗效。方法2003年1月—2006年6月采用3DCRT结合TACE治疗中晚期原发性肝癌53例。KPS评分≥60;肝功能Child-pugh A级或B级;门静脉主干无癌栓;白细胞和血小板均在正常范围;患者不愿手术或外科医生会诊无手术指征者。按全国肝癌诊疗规范临床诊断原发性肝癌53例,其中12例有肝穿刺病理或细胞学结果,肿瘤<3cm5例,3～5cm23例,>5cm25例。结果CR9例(17%),PR28例(54%),NC9例(17%),PD5例(11%),总有效率(CR+PR)为71%。结论三维适形放疗结合TACE为中晚期肝癌提供了一条有效的治疗方法。可有效控制肿瘤,解除患者痛苦,提高患者的生存质量和生存期。
Objective To observe the efficacy of interventional therapy combined with three-dimensional conformal radiotherapy in the treatment of advanced hepatocellular carcinoma. Methods From January 2003 to June 2006, 53 patients with advanced primary liver cancer were treated with 3DCRT and TACE. KPS score ≥60; Liver function Child-pugh class A or B; portal vein tumor thrombus; white blood cells and platelets are in the normal range; patients do not want surgery or surgeon consultation without surgical indications. According to the national norms of diagnosis and treatment of liver cancer 53 cases of primary liver cancer diagnosis, of which 12 cases of liver biopsy or cytology results, tumor <3cm5 cases, 3 ~ 5cm23 cases,> 5cm25 cases. Results CR9 cases (17%), PR28 cases (54%), NC9 cases (17%), PD5 cases (11%) and total effective rate (CR + PR) were 71%. Conclusion Three-dimensional conformal radiotherapy combined with TACE provides an effective treatment for advanced liver cancer. Can effectively control the tumor, relieve the suffering of patients, improve patient quality of life and survival.