尽管阿司匹林的毒性是众所周知的,目前仍是人们常用的镇痛解热药。然而它在儿童中已造成许多意外的、因自体中毒而致命的病例,尤其是发热的婴儿,治疗量过大可导致严重的酸中毒、酮症和低钾。近来人们已逐渐意识到,即使是治疗剂量的阿司匹林也会引起Reye氏综合征。这一罕见、但会致死的婴儿和儿童疾病于1963年首次被明确报道,但可以推断的病例更早就有过报道。典型的病例是在一个流感或水痘后复原的病孩突然出现顽固性呕吐,伴有倦怠、嗜眠、定向力障碍和烦躁,若 Although the toxicity of aspirin is well known, it is still commonly used analgesic antipyretics. However, it has caused many unexpected and fatal cases of autonomic poisoning in children, especially in infants who are overheated, resulting in severe acidosis, ketosis and hypokalemia. Recently, people have gradually realized that even the therapeutic dose of aspirin can cause Reye’s syndrome. This rare but fatal infant and childhood illness was first reported explicitly in 1963, but it can be inferred earlier cases have been reported. A typical case is a sudden onset of recalcitrant vomiting in a child recovering from a flu or chickenpox with burnout, narcolepsy, disorientation and irritability. If