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本文合成了25个5-氟尿嘧啶的非环核苷衍生物及类似物,以寻找毒副反应小,安全范围广的新5-氟尿嘧啶类抗肿瘤药。以2,4-双三甲基硅烷-5-氟尿嘧啶或1-苯磺酰基-4-三甲基硅烷-5-氟尿嘧啶和各种氯甲基烷醚为原料,用碘化钠或无水四氯化锡作催化剂,在乙腈中进行缩合而得。
In this paper, 25 5-fluorouracil non-nucleoside derivatives and their analogues were synthesized in order to find a new 5-fluorouracil antineoplastic agent with a small toxicity and a wide range of safety. Using 2,4-ditrimethylsilane-5-fluorouracil or 1-phenylsulphonyl-4-trimethylsilane-5-fluorouracil and various chloromethylalkylethers as starting materials, sodium iodide or anhydrous tetrakis Tin chloride as a catalyst, derived from condensation in acetonitrile.