前药的概念前药(Prodrug)的概念可用下图予以说明。一种药物由于某些不利的理化性质,在体内不能克服特殊屏障而使应用受限。通过化学修饰,制成前药,即能透过有关屏障。引入基团(Promoiety)和药物形成的键经酶或非酶的作用而断裂,断下的基团随即迅速消除。 The concept of prodrug The concept of prodrug can be illustrated by the following figure. A drug is limited in application by the inability of the body to overcome a particular barrier due to some adverse physico-chemical properties. By chemical modification, made of prodrugs, that is, through the barrier. The introduction of the group (Promoiety) and drug-formed bonds are cleaved by enzymatic or non-enzymatic action and the broken groups are immediately eliminated.