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目的 观察补阳还五汤提取物 (BDE)对脑缺血再灌流后一氧化氮合酶 (NOS)活性的影响。方法 建立大鼠大脑中动脉栓塞 (MCAO)及再灌流模型 ,利用NADPH d组织化学方法检测大脑皮质神经元内NOS活性。结果 BDE组NOS活性与对照组比较 ,有显著性差异 (P <0 .0 5 )。结论 BDE抑制神经元NOS活性 ,对脑缺血再灌流损伤具有脑保护作用。
Objective To observe the effect of Buyang Huanwu Decoction (BDE) on the activity of nitric oxide synthase (NOS) after cerebral ischemia and reperfusion. Methods Rat middle cerebral artery occlusion (MCAO) and reperfusion models were established. NADPH d histochemical method was used to detect NOS activity in cerebral cortical neurons. Results Compared with the control group, the NOS activity in BDE group was significantly different (P < 0.05). Conclusion BDE inhibits the activity of NOS in neurons and has a protective effect on cerebral ischemia-reperfusion injury.